Annals of African Surgery. Vol 16, No 1 (2019):

EMLA cream vs 10% lidocaine cream for attenuating venous cannulation pain – a clinical trial
Oluwayemisi Bamidele Oluwadun, Oyebola Olubodun Adekola, Olufemi I.O. Dada, Simeon O. Olanipekun, Adebayo Sulaimon Adetunji, John Olutola Olatosi, Olushola Temitayo Kushimo

Background: Venous cannulation is a painful procedure that is associated with anxiety, distress and discomfort. But pain is frequently overlooked in adults.Aims and Objective: We compared the efficacy of 5% EMLA cream and 10% lidocaine cream in attenuating pain associated with peripheral venous cannulation.Methods: This prospective, randomized, placebo-controlled trial was conducted in 102 ASA I and II adults scheduled for elective surgery. They were randomly allocated by blind balloting to one of three groups: group E had 1.5 mL of EMLA cream, group L 1.5 mL of 10% lidocaine cream, and group P 1.5 mL KY gel. All cream was applied over a visible vein for 60 min with occlusive dressing. Pain was evaluated using visual analogue scale (VAS) and verbal rating scale (VRS).Results: The mean VAS score was significantly lower with either EMLA cream (2.62??1.76 cm) or 10% lidocaine cream (1.85??1.58 cm) than with placebo (4.78 ??1.88 cm), p<0.001. Most patients who received EMLA cream (76.5%) or 10% lidocaine cream (70.6%) compared with placebo (55.9%) had mild pain during cannulation using VRS.Conclusion: The eutectic mixture of local anesthetic cream and lidocaine cream attenuated pain associated with peripheral venous cannulation to varying degrees.Keywords: Venous cannulation pain, 10% lidocaine, EMLA, VAS, VRS, Side effects

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