Tropical Journal of Pharmaceutical Research. Vol 18, No 1 (2019):167-171

Anesthetic and hemodynamic effects of etomidateremifentanil combination in laparoscopic surgery
Yu Yao, Feng-juan Wang, Jie Liu, Zhen-zhong Wu, Jin-zhuo Wang, Jingming Zhao

Purpose: To study the anesthetic and hemodynamic effects of etomidate-remifentanil combination treatment in laparoscopic surgery.Methods: Patients scheduled for gynecological laparoscopic surgery (n = 120) were assigned to test and control groups (60 patients each). Etomidate combined with remifentanil anesthesia was used in the test group, while propofol-remifentanil combination anesthesia was used in the control group. The effect of anesthesia on awakening time, extubation time, pain relief time, systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) of patients before and after the extubation were observed and recorded for the two groups.Results: Excellent rating was 98.0 % in the test group, and was superior to the corresponding rating of 86.0 % in the control group. Anesthesia time, awakening time, extubation time and pain relief time were markedly shorter in the test group than in controls (p < 0.05). However, there were no significant differences in SBP, DBP and HR of patients with tracheal intubation between the two groups (p > 0.05). The results were similar in patients with laparoscopic placement. After laparoscopic placement and tracheal extubation, significant decreases in SBP and HR in the test group were seen, relative to control patients (p < 0.05).Conclusion: The anesthetic effect of etomidate combined with remifentanil is superior to that of propofol and remifentanil, and ensures stability of hemodynamic parameters such as SBP, DBP and HR during the period of anesthesia.Keywords: Etomidate, Remifentanil, Propofol, Laparoscopic surgery, Hemodynamic parameters

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